Antidepressant medications are highly effective in treating depression and anxiety, but many women have concerns about side effects, especially weight gain. For guidance on navigating medication classes and matching treatments to your biological profile, read our resource on finding the right antidepressant. While the typical weight gain associated with antidepressants is only about 0.4 to 1.1 pounds over six months, about 10–15% of women may gain five or more pounds in that